Applying Second i485

Yes, they will for sure.

Your question is not clear. I don’t think there is anything to do with interfiling here as both of you are primary in your own EB2 & EB3 queue and dependent on each other’s I-485 application. You can do interfile if one of you is primary for both EB2 & EB3 I-140, then you can interfile to switch EB category.

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